资源类型

期刊论文 60

年份

2023 2

2022 7

2021 11

2020 7

2019 2

2018 4

2017 3

2016 1

2015 4

2014 5

2013 2

2012 4

2010 3

2006 1

2002 2

2001 1

2000 1

展开 ︾

关键词

6G;广域覆盖信令小区;多维资源分配;深度Q网络(DQN) 1

COVID-19 1

DQ&P 1

GC-Q-TOFMS 1

H∞控制;零和动态博弈;强化学习;自适应动态规划;极小极大Q-学习;策略迭代 1

KTP 1

LC-Q-TOFMS 1

LC4CS 铝合金 1

LED,颜色漂移,光通量衰减,流明衰减 1

Q&P 1

Q值监测 1

SEIR+Q传染病动力学模型 1

个性化机器人 1

临床诊断标准 1

主动物品检测;深度Q学习网络;训练算法;服务机器人 1

习惯学习 1

二硫化铼;可饱和吸收体;二维材料;调Q光纤激光器 1

云制造 1

人为地形变化 1

展开 ︾

检索范围:

排序: 展示方式:

GC/LC-Q-TOFMS 两种技术联用同时筛查水果蔬菜中733 种农药残留 Article

庞国芳, 常巧英, 白若镔, 范春林, 张紫娟, 闫宏远, 吴兴强​​​​​

《工程(英文)》 2020年 第6卷 第4期   页码 432-441 doi: 10.1016/j.eng.2019.08.008

摘要:

本文通过创建LC-Q-TOFMS(525种农药)和GC-Q-TOFMS(485种农药和209种PCBs)两大精确质谱数数据库,开发了一次样品制备、两种高分辨质谱联用同时检测733种农药化学污染物残留的检测方法通过8种代表性水果蔬菜对联用技术的筛查农药范围、灵敏度、回收率和重现性等方法效能评价,显示出这项联用技术有三方面优势:①两种技术联用与单种技术相比,其发现能力分别提高了51.1%(GC-Q-TOFMS,485种)和39.6%(LC-Q-TOFMS,525种);②联用技术能够满足78%的农药筛查限(SDL)低于10 μg·kg–1,满足国际&ldquo

关键词: 农药残留     GC-Q-TOFMS     LC-Q-TOFMS     精确质量数据库     谱图库     水果蔬菜    

预腐蚀后拉伸超载对LC4CS铝合金疲劳性能的影响

蒋荟,杨晓华

《中国工程科学》 2006年 第8卷 第2期   页码 44-46

摘要:

采用预腐蚀后进行单次拉伸超载疲劳试验的方法,研究了腐蚀与超载对LC4CS材料疲劳寿命的影响。

关键词: LC4CS 铝合金     预腐蚀     超载     疲劳寿命    

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

《结构与土木工程前沿(英文)》 2014年 第8卷 第4期   页码 448-455 doi: 10.1007/s11709-014-0262-x

摘要: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

关键词: JH classification     Q and RMR classification     new method    

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

《医学前沿(英文)》 2022年 第16卷 第6期   页码 883-895 doi: 10.1007/s11684-022-0919-0

摘要: Metastasis and drug resistance are the leading causes of poor prognosis in patients with osteosarcoma. Identifying the relevant factors that drive metastasis and drug resistance is the key to improving the therapeutic outcome of osteosarcoma. Here, we reported that autophagy was highly activated in metastatic osteosarcoma. We found increased autophagolysosomes in metastatic osteosarcoma cell lines by using electron microscopy, Western blot, and immunofluorescence experiments. We further examined the expression of the autophagy-related genes Beclin1 and LC3B in 82 patients through immunohistochemistry and found that Beclin1 and LC3B were highly related to unfavorable prognosis of osteosarcoma. Knockdown of Beclin1 and LC3B reduced invasion, metastasis, and proliferation in metastatic osteosarcoma cells. In vitro and in vivo studies also demonstrated that inhibiting by 3-MA inhibited cell growth and metastasis. Moreover, we demonstrated that autophagy-related genes were activated by SEs and that the inhibition of SEs by JQ-1 decreased the metastasis of osteosarcoma. Overall, our findings highlighted the association of autophagy with osteosarcoma progression and shed new light on autophagy-targeting therapy for osteosarcoma.

关键词: osteosarcoma     autophagy     metastasis     drug resistance     Beclin1     LC3B    

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

《结构与土木工程前沿(英文)》 2014年 第8卷 第1期   页码 26-35 doi: 10.1007/s11709-014-0239-9

摘要: To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the load bearing capacity of high strength Q460 steel columns is investigated. The current approach of evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460 steel columns with due consideration to high temperature properties of high strength Q460 steel. The critical temperature of high strength Q460 steel column is presented and compared with mild steel columns. The proposed approach was validated by comparing the predicted load capacity with that evaluated through finite element analysis and test results. In addition, parametric studies were carried out by employing the proposed approach to study the effect of residual stress and geometrical imperfections. Results from parametric studies show that, only for a long column (slenderness higher than 75), the magnitude and distribution mode of residual stress have little influence on ultimate load bearing capacity of high strength Q460 steel columns, but the geometrical imperfections have significant influence on any columns. At a certain slenderness ratio, the stability factor first decreases and then increases with temperature rise.

关键词: high strength Q460 steel     load bearing capacity     temperature    

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

《医学前沿(英文)》 2022年 第16卷 第6期   页码 932-945 doi: 10.1007/s11684-022-0963-9

摘要: The dysfunction of Na+-Cl cotransporter (NCC) caused by mutations in solute carrier family12, member 3 gene (SLC12A3) primarily causes Gitelman syndrome (GS). In identifying the pathogenicity of R158Q and G212S variants of SLC12A3, we evaluated the pathogenicity by bioinformatic, expression, and localization analysis of two variants from a patient in our cohort. The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensional structure. Western blot showed a decrease of mutant Ncc. Immunofluorescence of the two mutations revealed a diffuse positive staining below the plasma membrane. Meanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCC R158Q/G212S. NccR156Q/G210S mice clearly exhibited typical GS features, including hypokalemia, hypomagnesemia, and increased fractional excretion of K+ and Mg2+ with a normal blood pressure level, which made NccR156Q/G210S mice an optimal mouse model for further study of GS. A dramatic decrease and abnormal localization of the mutant Ncc in distal convoluted tubules contributed to the phenotype. The hydrochlorothiazide test showed a loss of function of mutant Ncc in NccR156Q/G210S mice. These findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of GS.

关键词: Gitelman syndrome     mouse model     compound heterozygous     hypokalemia     Slc12a3    

LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter

Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI

《化学科学与工程前沿(英文)》 2012年 第6卷 第4期   页码 436-442 doi: 10.1007/s11705-012-1222-4

摘要: More and more herbal medicines are found to be the substrates of drug transporters. In this paper, chromatography/tandem mass spectrometry (LC/MS/MS) combined with radioisotope method was used for the quantification of catalpol, a traditional Chinese medicine, to study the affinity relationship between herbal medicines and transporters. Catalpol uptake experiment was carried out by using several transporters (OAT1, OCT2, OAT3, OATP1B1 and OATP2B1). And samples were precipitated with methanol and quantified with LC/MS/MS. The results show that catalpol has a good affinity with OCT2-transfected S2 cells. After studying drug-drug interaction between catalpol and C-tetraethylammonium (TEA), we found that catalpol is able to facilitate TEA transport mediated by OCT2, suggesting that catalpol could probably be a new promoter of OCT2.

关键词: catalpol     LC/MS/MS     OCT2    

新型电光调Q腔内倍频绿光激光器

陈飞,霍玉晶,何淑芳,冯立春

《中国工程科学》 2000年 第2卷 第4期   页码 39-42

摘要:

本文报道了一种新型的LD泵浦Nd:YVO4-KTP电光调Q绿光激光器,用单块KTP晶体同时作为电光调Q开关和Ⅱ类相位匹配的倍频晶体,减少了腔内损耗,提高了效率,得到了脉宽为12ns

关键词: KTP     绿光激光器     电光调Q开关     倍频    

Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

《中国工程科学》 2014年 第16卷 第1期   页码 59-65

摘要:

为满足汽车工业轻量化发展要求,以Q&P(quenching & partitioning)工艺为基础的先进高强度钢受到了广泛关注,为使其在普通热连轧生产线上实现工业化并广泛应用,本文对Q&P理念在热轧工艺中的应用进行了基础研究。结果表明在传统热处理Q&P工艺中引入热变形处理后,组织细化显著,并获得了一定量的残余奥氏体。实验钢在保持较高强度的同时获得了较大的强塑积,结合目前国内热连轧生产线以超快冷系统为核心的新一代控轧控冷(TMCP)技术的应用,确定了在热连轧生产线生产热轧Q&P钢(DQ(direct quenching

关键词: 先进高强度钢     Q&P     DQ&P     热轧     残余奥氏体    

光传送网中光监控通道信号Q值在线监测技术

唐勇,孙小菡,张明德,丁东

《中国工程科学》 2001年 第3卷 第12期   页码 71-75

摘要: 依据Q值与误码率(BER)的一一对应关系,提出了一种可在线监测OSC信号Q值的方案,并基于数字信号处理芯片(DSP)技术设计了监测模块,实现了OSC信号在线Q值监测。

关键词: 光传送网(OTN)     光监控通道(OSC)     运行、管理和维护(OAM)     Q值监测    

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

null

《医学前沿(英文)》 2018年 第12卷 第3期   页码 324-329 doi: 10.1007/s11684-017-0558-z

摘要:

Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes>200×109/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19+, CD20+, HLA-DR+, CD22+, CD5+, Kappa+, CD25dim, CD71dim, Lambda, CD7, CD10, CD23, CD34, CD33, CD13, CD14, CD117, CD64, CD103, and CD11c. The karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.

关键词: splenic lymphoma with villous lymphocytes     splenic marginal zone lymphoma     transformation     chromosome translocation    

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

《机械工程前沿(英文)》 2019年 第14卷 第4期   页码 489-495 doi: 10.1007/s11465-019-0554-x

摘要: Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which is widely used in coal equipment. In this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °C–1200 °C and strain rates of 0.05, 0.5, 5, and 15 s by using a Gleeble-3800 thermomechanical simulator. A constitutive equation was validated by referring to the Arrhenius equation during the characterization of hot workability. The computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing maps under different strain conditions were drawn. Analysis of the stress-strain relationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345R bimetal. The processing maps predicted that the optimal processing interval will increase with strain. Results showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature range varies from 1182 °C to 1200 °C and the strain rate interval is from 4.2 to 15 s .

关键词: BTW1/Q345R bimetal     constitutive equation     processing map     work hardening    

基于深度Q学习网络与新训练算法的服务机器人主动物品检测模型 Research Article

刘少鹏,田国会,崔永成,邵旭阳

《信息与电子工程前沿(英文)》 2022年 第23卷 第11期   页码 1673-1683 doi: 10.1631/FITEE.2200109

摘要: 因此,本文提出一种基于深度Q学习网络的AOD模型,并设计了一种新的模型训练算法。该模型旨在拟合各种动作Q值,包括状态空间、特征提取和多层感知机。

关键词: 主动物品检测;深度Q学习网络;训练算法;服务机器人    

Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

《医学前沿(英文)》 2010年 第4卷 第3期   页码 336-341 doi: 10.1007/s11684-010-0096-4

摘要: The autoimmune regulator (AIRE) is a crucial factor for the induction of central tolerance, and mutations in this gene lead to abnormal immune responses. However, the role of AIRE in autophagy in immune cells, especially in monocytes, is obscure. In the present study, we found that overexpression of AIRE in THP-1 human monocytes resulted in increased endogenous light chain 3 (LC3)-II level and elevated LC3 positive vesicles. Moreover, an autophagy inhibitor or knockdown of AIRE by small interference RNA attenuated these effects. In contrast, the expression of p62/SQSTM1 remained unchanged in THP-1 cells after the corresponding treatment. Our findings indicate that AIRE plays a role in the regulation of autophagy in THP-1 human monocytes.

关键词: autoimmune regulator     autophagy     monocytes     light chain 3 (LC3)    

Development of barium@alginate adsorbents for sulfate removal in lithium refining

Lisa Xu, Kaifei Chen, George Q. Chen, Sandra E. Kentish, Gang (Kevin) Li

《化学科学与工程前沿(英文)》 2021年 第15卷 第1期   页码 198-207 doi: 10.1007/s11705-020-1968-z

摘要: The demand for lithium has been steadily growing in recent years due to the boom of electric cars. High purity lithium is commonly used in the manufacture of battery grade lithium electrolyte. Sulfate residuals originating from acid leaching of lithium ores must be limited to below 20 mg·L during refining. There are methods to remove sulfate such as membrane processing and chemical precipitation using barium salts. However, membrane separation is unable to achieve the required purity while chemical precipitation often causes secondary contamination with barium and requires extra filtration processes that lead to increased processing costs. In this study, we developed a polymeric matrix entrapped with barium ions as a novel adsorbent to selectively adsorb sulfate in aqueous solutions. The adsorbent was prepared by dropwise injection method where alginate droplets were crosslinked with barium to form hydrogel microcapsules. In a typical scenario, the microcapsules had a diameter of 3 mm and contained 5 wt-% alginate. The microcapsules could successfully reduce sulfate concentration in a solution from 100 to 16 mg·L , exceeding the removal target. However, the microcapsules were mechanically unstable in the presence of an excess amount of sulfate. Hence, calcium ions were added as a secondary crosslinking agent to improve the integrity of the microcapsules. The two-step Ca/Ba@alginate microcapsules showed an exceptional adsorption performance, reducing the sulfate concentration to as low as 0.02 mg·L . Since the sulfate selective microcapsules can be easily removed from the aqueous system and do not result in secondary barium contamination, these Ca/Ba@alginate adsorbents will find applications in ultra-refining of lithium in industry.

关键词: barium@alginate     microcapsules     dropwise injection     sulfate removal     lithium    

标题 作者 时间 类型 操作

GC/LC-Q-TOFMS 两种技术联用同时筛查水果蔬菜中733 种农药残留

庞国芳, 常巧英, 白若镔, 范春林, 张紫娟, 闫宏远, 吴兴强​​​​​

期刊论文

预腐蚀后拉伸超载对LC4CS铝合金疲劳性能的影响

蒋荟,杨晓华

期刊论文

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

期刊论文

Superenhancers activate the autophagy-related genes Beclin1 and LC3B to drive metastasis and drug resistance

期刊论文

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

期刊论文

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

期刊论文

LC/MS/MS and radioisotope method combined for recognizing the affinity between catalpol and OCT2 transporter

Zhiyu ZHANG, Changxiao LIU, Duanyun SI, Rong LU, Xiulin YI

期刊论文

新型电光调Q腔内倍频绿光激光器

陈飞,霍玉晶,何淑芳,冯立春

期刊论文

Q&P 工艺理念在热轧先进高强度钢中的应用研究

袁国,康健,张贺,李云杰,胡虹玲,王国栋

期刊论文

光传送网中光监控通道信号Q值在线监测技术

唐勇,孙小菡,张明德,丁东

期刊论文

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

null

期刊论文

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

期刊论文

基于深度Q学习网络与新训练算法的服务机器人主动物品检测模型

刘少鹏,田国会,崔永成,邵旭阳

期刊论文

Autoimmune regulator regulates autophagy in THP-1 human monocytes

Liang SHI, Li-Hua HU, Yi-Rong LI

期刊论文

Development of barium@alginate adsorbents for sulfate removal in lithium refining

Lisa Xu, Kaifei Chen, George Q. Chen, Sandra E. Kentish, Gang (Kevin) Li

期刊论文